White sponge nevus is a condition characterized by the formation of white patches of tissue called nevi (singular: nevus) that appear as thickened, velvety, sponge-like tissue. The nevi are most commonly found on the moist lining of the mouth (oral mucosa), especially on the inside of the cheeks (buccal mucosa) . It is caused by a mutations in certain genes coding for keratin, which causes a defect in the normal process of keratinization of the mucosa
White sponge naevus (Mendelian Inheritance in Man [MIM] number 193900) is a rare genetic condition that causes white spongy lesions of the mucous membranes, most commonly the mouth From WikiProjectMed White sponge nevus WSN, is an autosomal dominant condition of the oral mucosa (the mucous membrane lining of the mouth). It is caused by a mutations in certain genes coding for keratin, which causes a defect in the normal process of keratinization of the mucosa Other names White sponge naevus , Cannon's disease , Hereditary leukokeratosis of mucosa , White sponge nevus of Cannon , Familial white folded dysplasia ,   or Oral epithelial nevus  White sponge nevus has an autosomal dominant pattern of inheritance
White sponge nevus. At least five KRT13 gene mutations have been found to cause white sponge nevus, a condition that results in the formation of white patches of tissue called nevi (singular: nevus) that appear as thickened, velvety, sponge-like tissue. These nevi most often occur on the mouth (oral) mucosa (plural: mucosae). Rarely, white sponge nevus occurs on the mucosae of the nose. White sponge nevus has also been called WSN, congenital leukokeratosis, familial white folded mucosal dysplasia, leukoderma exfoliativum mucosae oris, hereditary leukokeratosis, white folded gingivostomatitis, oral epithelial nevus, nevus of Cannon or white sponge nevus of Cannon 2) Other Ways to Partner. White sponge nevus of cannon. Enter a disease name or synonym to search NORD's database of reports. To search for patient organizations and other pages related to this topic, use the Advanced Search function at the top right corner of the page Leukoedema lesions disappear when the mucosa is stretched, which helps to differentiate it from other white lesions in the mouth. The differential diagnosis is with leukoplakia, oral candidiasis, oral lichen planus, white sponge nevus, morsicatio buccarum, hereditary benign intraepithelial dyskeratosis and dyskeratosis congenita
White sponge nevus almost always presents during childhood and there is no gender predilection. It presents in the mouth, most frequently as a thick bilateral white plaque with a spongy texture, usually on the buccal mucosa, but sometimes on the labial mucosa, alveolar ridge or floor of the mouth. The gingival margin and dorsum of the tongue are almost never affected . Is white sponge nevus syndrome autosomal dominant or recessive? dominant. In which area is the white sponge nevus syndrome primarily seen? buccal mucosa White sponge nevus (WSN) is an autosomal-dominant disease that is caused by the mutation of certain keratin genes. Keratin is the structural protein of epithelial cells In the mouth it appears similar to white sponge nevus, with painless, diffuse, folded and spongy white plaques. Hereditary benign intraepithelial dyskeratosis - Wikipedia The differential diagnosis includes other oral white lesions such as Leukoplakia , squamous cell carcinoma, oral candidiasis, lichen planus, white sponge nevus and contact.
.g., leukoedema, leukoplakia, irritation, chewing tobacco dysplasia, lichen planus, Darier's disease, dyskeratosis congenita. Management No treatmen White sponge nevus (WSN) is a rare autosomal dominant disorder with variable penetrance (1). It was first described by Hyde in 1909 (2); in 1935 Can-non named it white sponge nevus (3). Several other names have been applied to this condition: Hyde-Cannon's disease, familial white folded dysplasia White sponge nevus (WSN) is a rare hereditary dyskeratotic hyperplasia of mucous membranes. It is an autosomal dominant disorder with variable penetrance. We report a case of WSN in a healthy 21-year-old male with no history of familial involvement White sponge nevus (WSN) is an autosomal dominant hereditary disease. Keratin 4 (KRT4) and Keratin 13 (KRT13) gene mutations were involved in the WSN.We recruited two WSN Chinese families, and oral lesion biopsy with hematoxylin and eosin staining showed that patients had significant pathological characteristics White sponge nevus, or Cannon disease, is a relatively uncommon genetic disorder that is inherited as an autosomal dominant trait .The penetrance is high, but expressivity is variable .Asymptomatic, white, folded mucosal plaques that often have a spongy texture characterize this disorder [1, 3].These plaques primarily involve the buccal mucosa, the labial mucosa, the alveolar ridge.
The hereditary nature of white sponge nevus is recognizable, as it can be traced through various members of a family.1'14 When an initial white sponge nevus is discovered in a patient, subsequent examinations may reveal similar lesions in other members of the patient's family for treating other KRT-associated diseases. Introduction White sponge nevus (WSN) is a rare hereditary leuco-keratosis that was first described by Hyde in 1909 (Ref. 1); the term white sponge nevus was first coined by Cannon in 1935 (Ref. 2). The onset of WSN is early in life, and both sexes are affected equally. Lesions of WSN are easily. Synonyms for white sponge nevus in Free Thesaurus. Antonyms for white sponge nevus. 1 synonym for nevus: birthmark. What are synonyms for white sponge nevus
White sponge nevus WSN, is an autosomal dominant  condition of the oral mucosa (the mucous membrane lining of the mouth). It is caused by a mutations in certain genes coding for keratin, which causes a defect in the normal process of keratinization of the mucosa. This results in lesions which are thick, white and velvety on the inside of the cheeks within the mouth Microscopic (histologic) description. Parakeratosis, acanthosis with formation of large blunt rete ridges and spongiosis. Extensive vacuolation of suprabasal keratinocytes. Dyskeratotic cells exhibit dense peri and paranuclear eosinophilic condensations, which correspond to tonofilament aggregates. Abundant Odland bodies (keratinosome, membrane. White sponge nevus is a disease component of a group of inherited diseases that produce a white, bilateral, keratinized appearance typically appearing on the buccal mucosa. The term used for this type of genetically induced lesion within the family of white lesions is genokeratoses. White sponge nevus (WSN) is an autosomal-dominant disease that. White sponge nevus is a rare autosomal dominant disorder of noncornifying squamous epithelial differentiation that presents clinically as white, soft, thick plaques of the oral mucosa. Less frequently, the mucous membranes of the nose, esophagus, genitalia, and rectum are involved WHITE SPONGE NEVUS Definition White sponge nevus (WSN) is a rare autosomal dominant disorder which was first described by Hyde in 1909, but the term was coined in 1935 by Cannon. It was also named as familial white folded dysplasia. The condition predominantly affects non-cornifying stratified squamous epithelia, such a
The differential diagnosis of white sponge nevus includes oral lesions of leukoplakia, chemical burns, trauma, syphilis, tobacco and betel nut use. White sponge nevus may also be confused with candidiasis, but fungal examination, the histology of biopsy specimens, and the response to antifungal agents will be the differentiating factors The name white sponge nevus was coined by Cannon in 1935 (9), but the disease was described earlier by Hyde. It is a rare condition that has a dominant autosomal inheritance; typically, 50% of children of an affected parent will inherit the condition Leukoplakia is a firmly attached white patch on a mucous membrane which is associated with increased risk of cancer. The edges of the lesion are typically abrupt and the lesion changes with time. Advanced forms may develop red patches. There are generally no other symptoms. It usually occurs within the mouth, although sometimes mucosa in other parts of the gastrointestinal tract, urinary tract.
(C and D) White spongy nevus lesions in a 26-year-old woman demonstrating diffuse, symmetrical, thickened, corrugated, and white plaques on the bilateral buccal mucosae. White spongy nevus is a rare genetically-determined skin disorder that is inherited as an autosomal dominant trait with a high degree of penetrance and variable expressivity White sponge nevus (WSN, or white sponge naevus, Cannon's disease, hereditary leukokeratosis of mucosa, white sponge nevus of Cannon, familial white folded dysplasia, or oral epithelial nevus), is an autosomal dominant condition of the oral mucosa (the mucous membrane lining of the mouth). It is caused by a mutations in certain genes coding for keratin, which causes a defect in the normal. White sponge nevus definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now White sponge nevus is a rare, autosomal dominant hereditary genodermatosis with variable penetrance, although sporadic cases have been reported. It was described by Hyde in 1909 with the name leukokeratosis and in 1935, Cannon coined the term white sponge nevus. The pathophysiology is not fully understood It shows an autosomal dominant inheritance.13 Lesions have been observed in the oral cavity and, occasionally, in the nasal, pharyngeal, esophageal, vaginal, anal, and rectal mucosa.4'12 A number of different names have been used to describe this con- dition, but the term white sponge nevus, originally suggested by Cannon,13 is still widely.
another name for white sponge nevus: Definition. Cannon's Disease: Term. white sponge nevus has high ___ and variable ____ Definition. high penetrance and variable expressivity: Term. white sponge nevus is a defect of _____ Definition. keratinization in mucosa: Term. when do white sponge nevus lesions appear Your Name: * Subject: Send me a copy of this email. Retype the code from the picture: The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent. White Sponge Nevus of Glans Penis Show all authors. Rashi Pangti 1. Rashi Pangti White sponge nevus is a rare hereditary cause of oral leukoplakia associated with mutations in the keratin 4 and 13 genes. 82, 83 The lesions clinically resemble oral candidiasis and are typically present from birth, although recognition may be delayed. Histologically, there is acanthosis with cytoplasmic clearing and perinuclear accumulation. Leukoplakia Leukoedema White Sponge Nevus Leukoplakia (White patch) a predominantly white lesion of the oral mucosa that cannot be characterized as any other definable lesion. - white patch or plaque, 5 mm or more that cannot be removed by scraping - firmly attached to the oral mucosa Define white sponge nevus. white sponge nevus synonyms, white sponge nevus pronunciation, white sponge nevus translation, English dictionary definition of white sponge nevus. geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used.
Cannon diseases  This is another name for White sponge nevus , an autosomal dominant condition of the oral mucosa caused by a mutations in certain genes coding for keratin. The clinical characteristics of the white sponge nevus were first described by Hyde in 1909, followed by Cannon in 1935.A . The symmetric lesions of this autosomal dominant trait may better be called white sponge hyperplasia of the mucosa. - The term basal cell nevus is incorrect because it denotes neoplastic skin lesions
Cannon diseases  This is another name for White sponge nevus , an autosomal dominant condition of the oral mucosa caused by a mutations in certain genes coding for keratin. The clinical characteristics of the white sponge nevus were first described by Hyde in 1909, followed by Cannon in 1935.A. Benson Cannon (1888-1950), (Fig. 4), was an. Background: White sponge naevus (WSN) is a rare, autosomal dominant disorder that predominantly affects noncornified stratified squamous epithelia, most commonly the buccal mucosa. Clinically, WSN manifests as thickened spongy mucosa with a white opalescent tint in the mouth and may be confused with other disorders that cause white lesions on oral mucosa
What are 4 histologic features of white sponge nevus? 1 Acanthosis 2 Hyperparakeratosis 3 Intracellular edema 4 Parakeratin plugs running into the spinous layer Name the clinical term for a white patch on the mucosa that does not wipe off and is no other specific dz Name two ways you can differentiate White Sponge Nevus from leukoplakia. White sponge nevus 1) Affects kids 2) Is autosomal dominant - transmitted Define carcinoma-in-situ. Carcinoma that does not invade the basal cell layer (basement membrane intact) Squamous cell carcinoma is the (#) leading cause of cancer deaths. 6t Leukoedema of the Oral Mucosa Possibly an Acquired White Sponge Nevus Scott C. Duncan, MD, W. P. Daniel Su, MD \s=b\Leukoedema is a white or whitish- gray edematous lesion of the buccal and labial oral mucosa. The lesions may be diffuse or patchy, and are usually asymp- tomatic. Leukoedema may be confused with leukoplakia, Darier's disease, white sponge nevus, pachyonychia congenita, or.
Synonyms for white spruce in Free Thesaurus. Antonyms for white spruce. 1 synonym for white spruce: Picea glauca. What are synonyms for white spruce White sponge naevus This entry was posted in Oral Care and tagged Dyskeratosis congenita , Hereditary benign intraepithelial dyskeratosis , leukoedema , White Lesion Of the Oral Mucosa Part 1 , White sponge nevus on January 5, 2012 by meifong
The main differential diagnoses include white sponge nevus, leukoedema, oral koilocytoses, hairy leukoplakia, pagetoid squamous cell carcinoma in situ, and extramammary Paget's disease of the oral mucosa. The morphologic features of dyskeratotic pagetoid cells are distinctive and easily recognized as an incidental finding, thus preventing. White sponge nevus (WSN) is an autosomaldominantly inherited form of mucosal leukokeratosis. Defects in keratins, proteins that form the stress-bearing cytoskeleton in epithelia, have been shown to..
GENO-KERATOSIS-the name for a GROUP of lesions that cause white lesions caused by genetics (wide spread, asymptomatic)..the ONE that a Dentist should remember is WHITE SPONGE NEVUS (Autosomal Dom) White areas can indicate many other conditions besides cancer, such as a yeast infection (candidiasis), thick white folds (a hereditary condition called white sponge nevus), a white line running along the inside of the cheek opposite the teeth (linea alba), and a grayish white area of the mucosa (leukoedema) White sponge nevus WSN, is an autosomal dominant condition of the oral mucosa. It is caused by a mutations in certain genes coding for keratin, which causes a defect in the normal process of keratinization of the mucosa. This results in lesions which are thick, white and velvety on the inside of the cheeks within the mouth there is no specific name for them. It has been estimated that palatal tori occur in 20- White sponge nevus, hered-itary benign intraepithelial dyskeratosis, and dyskeratosis congenital. All are extremely rare. a variety of other factors have been implicated. Withdrawal of certain foods such as cheese, tomato products and gluten, as.
Other conditions that can involve similar white plaques include oral lichen planus, candidiasis, lupus erythematosus, nicotinic stomatitis, graft-vs-host disease, white sponge nevus, frictional hyperkeratosis, and squamous cell carcinoma. 1. MANAGEMENT • White Surface Lesions • Surface Debris White Lesions Hairy tongue Leukoedema White sponge nevus Hairy leukoplakia Lichen planus Nicotinic stomatitis Hyperkeratosis Epithelial dysplasia Carcinoma-in-situ Squamous cell carcinoma black or other colors depending on the patient's diet and habits. Hairy tongu The white sponge nevus of Cannon is characterized by surface parakeratosis and hydropic swelling of the epithelial cells that extends into the rete ridges but spares the basal layer.17,18 The. White Sponge Nevus. With white sponge nevus there is a defect in the genes that express. Keratin 4 and keratin 13. Rare genodermatosis that affects persons of a tri-racial ancestry who originally lived in North Carolina; inherited autosomal dominant; develops oral and occular lesions Hereditary conditions Leukoedema White sponge nevus Hereditary benign Intraepithelial dyskeratosis Keratosis follicularis Pachyonychia congenita Dyskeratosis congenita Incontinentia pigmenti Ptylosis syndrome Leukoplakia and Malignancies Chronic cheek biting Friction or trauma associated leukoplakia Idiopathic leukoplakia Tobacco associated leukoplakia (a) homogeneous leukoplakia (b.
The most commonly affected site is the anterior two-thirds of the dorsal tongue, although these benign red and white lesions can also present on other oral mucosal sites. 4,5 Geographic tongue has a number of monikers, including lingua geographica, erythema migrans, exfoliation areata lingua, superficial migratory glossitis, lingual dystrophy. Differential diagnosis. Clinical differential diagnosis of FEH includes irritation fibromas, mucosal neuromas, and white sponge nevus. 5-7 Irritation fibromas usually present as soft, mucosa-coloured papules along the buccal occlusal line, as they usually arise secondary to irritation or masticatory trauma. 5 Mucosal neuromas usually present in early childhood as multiple pink, pediculated. White sponge nevus in the oral cavity: case report anda review of literature Abstract Introduction. White sponge nevus (WSN) is an uncommon white lesion mainly affecting the oral mucosa. This is an autosomal dominant hereditary disease with mutations in Keratin 4 and 13 genes White sponge nevus (WSN) A key characteristic, which gives the condition its name, is beaded hair resembling beads on a string. This is somewhat misleading as these hairs can be difficult to identify in many patients and hair fragility with or without varying degrees of alopecia is a more consistent finding. Like all other branches of.
White Spongy nevus, Cannon disease, Oral Mucosa, White plaques, Case reports. Introduction. White sponge nevus (WSN) is an inherited disease that produces a white, bilateral, keratinized appearance typically appearing on the buccal mucosa. This benign rare disorder was initially described by Hyde in 1909 and coined by Canon in 1935 1 Retrieved 6 May Andrews' Diseases of the Skin: In it was decided that the name of leukoplakia should be limited only to a clinical diagnosis defined by exclusion of other white lesions such as oral lichen planus, white sponge nevus, nicotine stomatitis, leukoedema etc 5 Human Phenotype Ontology, a standardized vocabulary of phenotypic abnormalities encountered in human disease. With unmatched depth it enables clinicians to record and analyse data with extremely accurate computer interpretable ontology terms. Developed by The Monarch Initiative Topics in other languages. German (Deutsch) Behandlungen; Hauterkrankungen; Pigmentierung, Hyperpigmentierung und Lösungen. Pigmentstörungen; Traditionelle depigmentierende Substanzen; Präsentation von Globale Dermatologie; Sexuell übertragbare Krankheiten (STD) Arabic (العربية) Chinese (中文) 汉语; 漢語; Spanish (Español. White sponge nevus is a disease component of a group of inherited diseases that produce a white, bilateral, keratinized appearance typically appearing on the buccal mucosa. The term used for this type of genetically induced lesion within the family of white lesions is genokeratoses
Marrelli M, Tatullo M, Dipalma G, Inchingolo F. Oral infection by Staphylococcus aureus in patients affected by White Sponge Nevus: a description of two cases occurred in the same family. Int J Med Sci. 2012;9(1):47-50 searching for Nevus 259 found (649 total) alternate case: nevus. White sponge nevus (568 words) exact match in snippet view article find links to article White sponge nevus WSN, is an autosomal dominant condition of the oral mucosa (the mucous membrane lining of the mouth). It is caused by a mutations i
Monilethrix. Other names: Moniliform hair syndrome. Beaded hair (60x magnification). Monilethrix (also referred to as beaded hair) is a rare autosomal dominant hair disease that results in short, fragile, broken hair that appears beaded. It comes from the Latin word for necklace ( monile) and the Greek word for hair ( thrix ) Oral leukoplakia is a focal white plaque varying in size and shape without any specific clinical or histological characteristic. Hence the diagnosis of leukoplakia is established by a process of exclusion, ruling out all other causes of white lesions such as candidiasis, white sponge nevus, leukoedema, frictional keratosis, etc. White Lesions. White lesions of the oral mucosa are a multifactorial group of disorders, the color of which is produced by the scattering of light through an altered epithelial surface. These lesions are classified into two groups: (1) attached to the oral mucosa and (2) scraped off from the oral mucosa. The diagnosis and differential diagnosis. Nevus (or naevus, plural nevi or naevi, from nævus, Latin for birthmark ) is the medical term for sharply-circumscribed and chronic lesions of the skin. These lesions are commonly named birthmarks and moles. Nevi are benign by definition. However, 50% of malignant melanomas (a skin cancer) arise from pre-existing naevi KRT4 (White sponge nevus) KRT5 (Epidermolysis bullosa simplex) KRT8 (Familial cirrhosis) KRT10 (Epidermolytic hyperkeratosis) KRT12 (Meesmann juvenile epithelial corneal dystrophy) KRT13 (White sponge nevus) KRT14 (Epidermolysis bullosa simplex) KRT17 (Steatocystoma multiplex) KRT18 (Familial cirrhosis) KRT81/KRT83/KRT86 (Monilethrix
Finally, the chapter about tumors and cysts of the epidermis includes, inappropriately, oral white sponge nevus, leukoedema of the oral mucosa, and lingua geographica. In summary, the lack of order in this chapter makes it difficult for a student who seeks to be enlightened about the diverse hamartomas, neoplasms, and cysts included in it This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13 White Sponge Nevus is a very rare disorder and large studies have not been conducted. All patients with White Sponge Nevus who have been tested and reported in the literature (9 families) were found to have a mutation in one of the two mucosal keratin genes, KRT4 and KRT13
Bradykinesia. MalaCards based summary : Waisman Syndrome, also known as bgmr, is related to white sponge nevus 1 and pettigrew syndrome, and has symptoms including tremor, bradykinesia and muscle rigidity. [malacards.org] Seizure 0001250 Strabismus Cross-eyed Squint Squint eyes [ more ] 0000486 5%-29% of people have these symptoms Dementia. - White sponge nevus presents as bilateral symmetric white, soft, spongy or velvety thick plaques of the buccal mucosa. However, other sites in the oral cavity may be involved including the ventral tongue, floor of the mouth, labial mucosa, soft palate and alveolar mucosa
Pigmented lesions as white lesion may present in children as in adults Linea alba, Leukoedema, White sponge nevus in which all are asymptomatic  while red purpul lesions could be due to local or systemic reason resulting in Petechiae, Purpura, Ecchymosis WSN - White sponge nevus of cannon. Looking for abbreviations of WSN? It is White sponge nevus of cannon. White sponge nevus of cannon listed as WSN. White sponge nevus of cannon - How is White sponge nevus of cannon abbreviated? geography, and other reference data is for informational purposes only. This information should not be. Variants include verrucous epidermal nevus, nevus sebaceous, nevus comedonicus, eccrine nevus, apocrine nevus, Becker's nevus, and white sponge nevus. A 22-year-old girl approached us with complaints of blackish-colored hard growth, increasing in size over the right post-auricular region since 5 years Find link is a tool written by Edward Betts.. searching for Nevus 260 found (649 total) alternate case: nevus White sponge nevus (568 words) exact match in snippet view article find links to article White sponge nevus WSN, is an autosomal dominant condition of the oral mucosa (the mucous membrane lining of the mouth). It is caused by a mutations i